反应详情

温度

20 °C

A mixture of methyl 4-(1-phenoxyethyl)benzoate (0.7 g, 2.7 mmol), lithium hydroxide monohydrate (571 mg, 13.6 mmol), tetrahydrofuran (15 mL), methanol (5 mL) and water (5 mL) was stirred at 20° C. for 4 hours. The mixture was adjusted to pH=1 with concentrated hydrochloric acid and then extracted with ethyl acetate (15 mL×3). The combined organic phase was dried by sodium sulfate, and then filtered. The filtrate was concentrated in vacuo to give 4-(1-phenoxyethyl)benzoic acid (0.5 g, 76%).

1. extractionextracted with ethyl acetate (15 mL×3)
2. dry with materialThe combined organic phase was dried by sodium sulfate
3. filtrationfiltered
4. concentrationThe filtrate was concentrated in vacuo