反应详情

A mixture of methyl 2-methyl-4-(phenoxymethyl)benzoate (66 mg, 0.26 mmol), lithium hydroxide (54 mg, 1.29 mmol), tetrahydrofuran (6 mL), methanol (2 mL), and water (2 mL) were stirred at room temperature for 12 hours. The mixture was neutralized to pH to 1 with concentrated hydrochloric acid and then extracted with ethyl acetate (20 mL×3). The combined organic phase was separated, dried over sodium sulfate, and then filtered. The filtrate was concentrated in vacuo to give 2-methyl-4-(phenoxymethyl)benzoic acid used in next step without further purification (42 mg, 67%). LRMS (M+H)− m/z: calcd 242.09. found 242.

1. extractionextracted with ethyl acetate (20 mL×3)
2. customThe combined organic phase was separated
3. dry with materialdried over sodium sulfate
4. filtrationfiltered
5. concentrationThe filtrate was concentrated in vacuo