反应详情

温度

20 °C

A mixture of methyl 2-methoxy-4-phenoxybenzoate (1.3 g, 5 mmol), lithium hydroxide monohydrate (571 mg, 13.6 mmol), tetrahydrofuran (150 mL), methanol (50 mL) and water (50 mL) was stirred at 20° C. for 4 hours. The mixture was adjusted to pH=1 with concentrated hydrochloric acid and then extracted with ethyl acetate (15 mL×3). The combined organic phase was dried by sodium sulfate, and then filtered. The filtrate was concentrated in vacuo to give 2-methoxy-4-phenoxybenzoic acid (1 g, 82%).

1. extractionextracted with ethyl acetate (15 mL×3)
2. dry with materialThe combined organic phase was dried by sodium sulfate
3. filtrationfiltered
4. concentrationThe filtrate was concentrated in vacuo