反应详情

To a solution of methyl 2-(4-bromophenyl)propanoate (2 g, 8.2 mmol) in tetrahydrofuran (30 mL) and water (20 mL) was added (1.2 g, 41 mmol) at room temperature, the mixture solution was stirred for 3 hours, then diluting with ethyl acetate (100 mL), and acidified with hydrochoric acid (6 M) to ph=3. The organic layer was dried over sodium sulfate, and concentrated to dry. The result residue 2-(4-bromophenyl)propanoic acid (2 g) was used directly for the next step without purification.

1. dry with materialThe organic layer was dried over sodium sulfate
2. concentrationconcentrated
3. customto dry
4. customThe result residue 2-(4-bromophenyl)propanoic acid (2 g) was used directly for the next step without purification