Hydrochloric Acid → HCID 89656186, compound

HRID 1502212Notes

Reaction equation

HRID 1502212 reaction equation
[OH-].[Na+].[O:3]([CH2:45][CH2:46][O:47][CH2:48][CH2:49][O:50][C:51]1[CH:56]=[CH:55][C:54]([C:57]2[C:58]([CH3:84])=[C:59]([C:66]([C:68]3[CH:69]=[C:70]4[C:75](=[CH:76][CH:77]=3)[NH:74][C:73](=[O:78])[N:72]([CH2:79][C:80]([O-:82])=[O:81])[C:71]4=[O:83])=[O:67])[N:60]3[C:65]=2[CH:64]=[CH:63][CH:62]=[CH:61]3)=[CH:53][CH:52]=1)[CH2:4][CH2:5][O:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[C:17]([CH3:44])=[C:18]([C:25]([C:27]3[CH:28]=[C:29]4[C:34](=[CH:35][CH:36]=3)[NH:33][C:32](=[O:37])[N:31]([CH2:38][C:39]([O:41]C)=[O:40])[C:30]4=[O:43])=[O:26])[N:19]3[C:24]=2[CH:23]=[CH:22][CH:21]=[CH:20]3)=[CH:12][CH:11]=1.Cl>CN1C(=O)CCC1>[O:3]([CH2:45][CH2:46][O:47][CH2:48][CH2:49][O:50][C:51]1[CH:56]=[CH:55][C:54]([C:57]2[C:58]([CH3:84])=[C:59]([C:66]([C:68]3[CH:69]=[C:70]4[C:75](=[CH:76][CH:77]=3)[NH:74][C:73](=[O:78])[N:72]([CH2:79][C:80]([OH:82])=[O:81])[C:71]4=[O:83])=[O:67])[N:60]3[C:65]=2[CH:64]=[CH:63][CH:62]=[CH:61]3)=[CH:53][CH:52]=1)[CH2:4][CH2:5][O:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[C:17]([CH3:44])=[C:18]([C:25]([C:27]3[CH:28]=[C:29]4[C:34](=[CH:35][CH:36]=3)[NH:33][C:32](=[O:37])[N:31]([CH2:38][C:39]([OH:41])=[O:40])[C:30]4=[O:43])=[O:26])[N:19]3[C:24]=2[CH:23]=[CH:22][CH:21]=[CH:20]3)=[CH:12][CH:11]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 131734303HCID 131734303, compound

Product 1

HCID 89656186HCID 89656186, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

A molar solution of sodium hydroxide (0.15 mL; 0.15 mmol) is added to a solution of methyl 2,2′-{oxybis[ethane-2,1-diyloxyethane-2,1-diyloxybenzene-4,1-diyl(2-methylindolizine-1,3-diyl)carbonyl(2,4-dioxo-1,4-dihydroquinazoline-6,3(2H)-diyl)]}diacetate (107 mg; 0.10 mmol) in 4 mL of NMP. The solution is stirred at ambient temperature for 24 h and then run into a hydrochloric acid solution (0.1 M). The precipitate obtained is filtered off, washed with water and dried under vacuum to give 101 mg (97%) of a yellow-orange powder.

Workup

  1. customThe precipitate obtained
  2. filtrationis filtered off
  3. washwashed with water
  4. customdried under vacuum

Sources & evidence

ORD record
ord-32c2b34a727545bf956cce7dfea2fc8d
Source dataset
uspto-grants-2015_12
Patent number
US09206177B2

Reaction notes

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