Potassium Carbonate → HCID 131734305, compound

HRID 1502215Notes

Reaction equation

HRID 1502215 reaction equation
C(=O)([O-])[O-].[K+].[K+].I[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[C:21]([CH3:51])=[C:22]([C:29]([C:31]3[CH:40]=[C:39]4[C:34]([C:35](=[O:50])[N:36]([CH2:42][C:43]([O:45][C:46]([CH3:49])([CH3:48])[CH3:47])=[O:44])[C:37](=[O:41])[NH:38]4)=[CH:33][CH:32]=3)=[O:30])[N:23]3[C:28]=2[CH:27]=[CH:26][CH:25]=[CH:24]3)=[CH:16][CH:15]=1.[NH2:52][CH2:53][CH2:54][O:55][CH2:56][CH2:57][OH:58].OS([O-])(=O)=O.[K+]>CN(C=O)C>[OH:58][CH2:57][CH2:56][O:55][CH2:54][CH2:53][NH:52][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[C:21]([CH3:51])=[C:22]([C:29]([C:31]3[CH:40]=[C:39]4[C:34]([C:35](=[O:50])[N:36]([CH2:42][C:43]([O:45][C:46]([CH3:49])([CH3:48])[CH3:47])=[O:44])[C:37](=[O:41])[NH:38]4)=[CH:33][CH:32]=3)=[O:30])[N:23]3[C:28]=2[CH:27]=[CH:26][CH:25]=[CH:24]3)=[CH:16][CH:15]=1

Participants

6

Reactant 4

HCID 11430Potassium CarbonateHCID 13578DiglycolamineHCID 516920Potassium bisulfateHCID 131734306HCID 131734306, compound

Product 1

HCID 131734305HCID 131734305, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Potassium carbonate (0.48 g, 3.46 mmol) and tert-butyl {7-[(1-{4-[(5-iodopentyl)oxy]phenyl}-2-methylindolizin-3-yl)carbonyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}acetate (0.50 g, 0.69 mmol) are added to a solution of 2-(2-aminoethoxy)ethanol (0.73 g, 6.93 mmol) in 7 mL of DMF. The solution is stirred for 24 h at ambient temperature and then run into a molar solution of KHSO4. The precipitate formed is filtered off, washed with water and dried under vacuum to give 380 mg (yield: 79%) of a brown powder.

Workup

  1. customThe precipitate formed
  2. filtrationis filtered off
  3. washwashed with water
  4. customdried under vacuum

Sources & evidence

ORD record
ord-ffb340a85f8e42d5ba58633ff676817f
Source dataset
uspto-grants-2015_12
Patent number
US09206177B2

Reaction notes

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