反应详情

温度

0 °C

In a typical reaction, a mixture of about 3 equivalents of triphenylphosphine and trifluoroacetic acid in carbon tetrachloride is cooled to about 0° C. in an ice bath and a 20% excess of triethylamine is added. With continued cooling, about a 20% excess of p-methoxyaniline in carbon tetrachloride is slowly added. After completion of the addition, the mixture is heated to about 70° C. for several hours. After cooling, the reaction mixture is extracted with hexane and the solvent evaporated to provide crude 2,2,2-trifluoro-N-(4-methoxyphenyl)acetimidoyl chloride.

1. customIn a typical reaction
2. additionis slowly added
3. additionAfter completion of the addition
4. temperaturethe mixture is heated to about 70° C. for several hours
5. temperatureAfter cooling
6. extractionthe reaction mixture is extracted with hexane
7. customthe solvent evaporated