Bicarbonate Ion → 2-Hydroxy-3-methoxy-3-(4-morpholinophenyl)propanenitrile

HRID 150327Notes

Reaction equation

HRID 150327 reaction equation
[CH3:18][Si:19]([CH3:20])([CH3:21])[C:22]#[N:23].[CH3:1][O:2][CH:3]([CH:4]=[O:5])[c:6]1[cH:7][cH:8][c:9]([N:12]2[CH2:13][CH2:14][O:15][CH2:16][CH2:17]2)[cH:10][cH:11]1.[CH3:29][CH2:30][O:31][CH2:32][CH3:33].[CH3:34][CH2:35][O:36][C:37]([CH3:38])=[O:39].[I-:41].[I-:43].[Na+:28].[O-:24][C:25]([OH:26])=[O:27].[OH2:40].[Zn+2:42]>>[CH3:1][O:2][CH:3]([CH:4]([OH:5])[C:22]#[N:23])[c:6]1[cH:7][cH:8][c:9]([N:12]2[CH2:13][CH2:14][O:15][CH2:16][CH2:17]2)[cH:10][cH:11]1

Participants

10

Reactant 9

HCID 769Bicarbonate IonHCID 923Sodium ionHCID 962WaterHCID 3283Diethyl EtherHCID 8857Ethyl AcetateHCID 30165Iodide Ion2×HCID 32051Zinc(2+)HCID 82115Trimethylsilyl cyanideHCID 58432110HCID 58432110, compound

Product 1

HCID 584320842-Hydroxy-3-methoxy-3-(4-morpholinophenyl)propanenitrile

Sources & evidence

ORD record
ord-5a1c339332c7497eb3f5d4a4b6f8cada
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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