反应详情

温度

65 °C

Potassium carbonate(0.58 g), sodium iodide(0.21 g), and 5-(1H-benzimidazol-2-ylmethyl)-2-methyl-5H-furo[3,2-c]pyridine-4-one(0.39 g) were added to a DMF solution(30 ml) of 7-(2-chloroethoxy)-1-ethyl-3,3,5-trimethyl-1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione(0.47 g). The mixture was stirred at 65° C. overnight. The mixture was further stirred at 100° C. overnight. After the reaction mixture was condensed under reduced pressure, the residue was purified by silica gel column chromatography (ethyl acetate: methanol=95:5→85:15). The purified product was condensed to dryness under reduced pressure to give the title compound(0.44 g) as a white amorphous solid.

1. stirringThe mixture was further stirred at 100° C. overnight
2. customcondensed under reduced pressure
3. customthe residue was purified by silica gel column chromatography (ethyl acetate: methanol=95:5→85:15)
4. customcondensed to dryness under reduced pressure