反应详情

To a solution of 2-chloro-5-fluorobenzoic acid (50 mg) and 1-butanol (263 μL) in THF (0.5 mL) and DMF (3 mL) was added potassium t-butoxide (329 mg) and the solution was reacted at 120° C. for 10 minutes in a microwave synthesizer (Biotage, Initiator). The reaction mixture was cooled and acidified by addition of water and 2M hydrochloric acid, extracted with diethyl ether, and dried over anhydrous sodium sulfate. The solvent was removed in vacuo, and the residue was purified on column chromatography to obtain the titled compound (17 mg) as white powder.

1. customthe solution was reacted at 120° C. for 10 minutes in a microwave synthesizer (Biotage, Initiator)
2. temperatureThe reaction mixture was cooled
3. extractionextracted with diethyl ether
4. dry with materialdried over anhydrous sodium sulfate
5. customThe solvent was removed in vacuo
6. customthe residue was purified on column chromatography