2-Methoxyethanol → HCID 58266777, compound

HRID 1505975Notes

Reaction equation

HRID 1505975 reaction equation
[C:1]1([S:7]([N:10]2[C:14]3[CH:15]=[N:16][C:17]([C:20]#[N:21])=[C:18]([OH:19])[C:13]=3[C:12]3[CH:22]=[C:23]([Br:26])[CH:24]=[N:25][C:11]2=3)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:27][O:28][CH2:29][CH2:30]O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.N(C(OCC)=O)=NC(OCC)=O>CN(C=O)C.C(OCC)(=O)C>[C:1]1([S:7]([N:10]2[C:14]3[CH:15]=[N:16][C:17]([C:20]#[N:21])=[C:18]([O:19][CH2:30][CH2:29][O:28][CH3:27])[C:13]=3[C:12]3[CH:22]=[C:23]([Br:26])[CH:24]=[N:25][C:11]2=3)(=[O:8])=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

7

Reactant 4

HCID 80192-MethoxyethanolHCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 582664728-(Benzenesulfonyl)-12-bromo-3-hydroxy-5,8,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaene-4-carbonitrile

Product 1

HCID 58266777HCID 58266777, compoundYield 37%

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 9-benzenesulfonyl-3-bromo-5-hydroxy-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile (120 mg, 0.28 mmol), 2-methoxyethanol (128 μL, 1.60 mmol) and triphenylphosphine (315 mg, 1.60 mmol) in anhydrous DMF (1.25 mL) was treated dropwise with diethyl azodicarboxylate (252 μL, 1.60 mmol) and the mixture stirred at ambient temperature for 9 h. The mixture was diluted with ethyl acetate (15 mL) and washed with brine (3×10 mL), dried over anhydrous magnesium sulfate, filtered and evaporated in vacuo. The crude material was purified by column chromatography (silica, 5 g column, Si-SPE, 30-50% DCM in pentane) to afford the title compound (50 mg, 37%). 1H NMR (CDCl3, 400 MHz): 9.58 (s, 1H), 8.97 (d, J=2.3 Hz, 1H), 8.76 (d, J=2.3 Hz, 1H), 8.24-8.22 (m, 1H), 8.22-8.00 (m, 1H), 7.66-7.60 (m, 1H), 7.54-7.48 (m, 2H), 4.74-4.69 (m, 2H), 3.87-3.83 (m, 2H), 3.48 (s, 3H). LCMS (Method B): RT=4.25 min, M+H+=487/489.

Workup

  1. washwashed with brine (3×10 mL)
  2. dry with materialdried over anhydrous magnesium sulfate
  3. filtrationfiltered
  4. customevaporated in vacuo
  5. customThe crude material was purified by column chromatography (silica, 5 g column, Si-SPE, 30-50% DCM in pentane)

Sources & evidence

ORD record
ord-b7163fab3b034b0590cbf84233893116
Source dataset
uspto-grants-2015_12
Patent number
US09216980B2

Reaction notes

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