反应详情

温度

35 °C

To a stirred suspension of 1.5 g Vemurafenib base and 15 ml acetone (T=30-35° C.), 0.9 ml choline (45% in methanol) was added. The obtained solution was stirred for 5 min at 35° C., then cooled to RT and divided into three identical portions. All three portions were stirred O/N in open vials at RT. To the oily residues, 1.5 ml of solvent was added (vial 1: isopropanol, vial 2: ethyl acetate and vial 3: tert. butylmethylether). After treatment in an ultrasonic bath until a clear solution was obtained, the vials were stored in the refrigerator for 6 days, the precipitates were filtered off, washed with 1.5 ml of the same solvent which was used for precipitation and dried O/N at RT.

1. additionwas added
2. temperaturecooled to RT
3. stirringAll three portions were stirred O/N in open vials at RT
4. customAfter treatment in an ultrasonic bath until a clear solution was obtained
5. waitthe vials were stored in the refrigerator for 6 days
6. filtrationthe precipitates were filtered off
7. washwashed with 1.5 ml of the same solvent which
8. customwas used for precipitation
9. customdried O/N at RT