Pyrrolidine → HCID 71239270, compound

HRID 1508182Notes

Reaction equation

HRID 1508182 reaction equation
[CH3:1][O:2][C:3](=[O:14])[C:4]([C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][C:7]=1[Cl:13])=[CH2:5].[NH:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1>C1COCC1.C(Cl)Cl>[CH3:1][O:2][C:3](=[O:14])[CH:4]([C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][C:7]=1[Cl:13])[CH2:5][N:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1

Participants

5

Reactant 2

HCID 31268PyrrolidineHCID 15734662HCID 15734662, compound

Product 1

HCID 71239270HCID 71239270, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
0 °C

Procedure

To a solution of 2-(2,4-dichlorophenyl)acrylic acid methyl ester (0.70 mmol) in 2 mL THF was added pyrrolidine (0.77 mmol) at 0° C. The reaction mixture was stirred at 0° C. for 50 min, diluted with DCM and washed with water. The organic layer was dried over MgSO4 and concentrated in vacuo to give the desired compound as pinkish oil;

Workup

  1. washwashed with water
  2. dry with materialThe organic layer was dried over MgSO4
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-b45d0e0397444c31a5c1299951861095
Source dataset
uspto-grants-2015_12
Patent number
US09221832B2

Reaction notes

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