Nitrogen → 2-Chloro-4-(5-chloro-2-thienyl)-6-methyl-1,3,5-triazine

HRID 1508701Notes

Reaction equation

HRID 1508701 reaction equation
[Cl:1][C:2]1[S:6][C:5]([C:7](=[NH:11])[NH:8][C:9]#N)=[CH:4][CH:3]=1.O=P(Cl)(Cl)[Cl:14].N#N.[CH3:19][C:20]#[N:21]>>[Cl:14][C:9]1[N:8]=[C:7]([C:5]2[S:6][C:2]([Cl:1])=[CH:3][CH:4]=2)[N:11]=[C:20]([CH3:19])[N:21]=1

Participants

5

Reactant 4

HCID 947NitrogenHCID 6342AcetonitrileHCID 24813Phosphorus oxychlorideHCID 178512257HCID 178512257, compound

Product 1

HCID 742210402-Chloro-4-(5-chloro-2-thienyl)-6-methyl-1,3,5-triazine

Conditions

Temperature
70 °C

Procedure

To a solution of reactant 3 in CH3CN was added reactant 2 and POCl3. The mixture was stirred at 70° C. overnight under. N2. TLC showed starting material was consumed. The mixture was then poured into NaHCO3 (aq) carefully and the precipitate collected. The dried sample was confirmed as desired product 2-chloro-4-(5-chlorothiophen-2-yl)-6-methyl-1,3,5-triazine 4.

Workup

  1. customwas consumed
  2. additionThe mixture was then poured into NaHCO3 (aq) carefully
  3. customthe precipitate collected

Sources & evidence

ORD record
ord-3346b58509d749b7a4c3b4f6baa525ec
Source dataset
uspto-grants-2015_12
Patent number
US09221843B2

Reaction notes

Loading…