Dimethylformamide → {2-[2-(3-Chloro-phenyl)-3-cyclopentyl-propionylamino]-thiazol-4-yl}-acetic acid ethyl ester

HRID 150874Notes

Reaction equation

HRID 150874 reaction equation
[CH2:24]([CH3:25])[O:26][C:27]([CH2:28][c:29]1[n:30][c:31]([NH2:34])[s:32][cH:33]1)=[O:35].[CH2:45]([Cl:46])[Cl:47].[CH3:48][N:49]([CH3:50])[CH:51]=[O:52].[CH:36]([N:37]([CH2:38][CH3:39])[CH:40]([CH3:41])[CH3:42])([CH3:43])[CH3:44].[Cl:18][C:19]([C:20]([Cl:21])=[O:22])=[O:23].[Cl:1][c:2]1[cH:3][c:4]([CH:8]([C:9](=[O:10])[OH:11])[CH2:12][CH:13]2[CH2:14][CH2:15][CH2:16][CH2:17]2)[cH:5][cH:6][cH:7]1>>[Cl:1][c:2]1[cH:3][c:4]([CH:8]([C:9](=[O:11])[NH:34][c:31]2[n:30][c:29]([CH2:28][C:27]([O:26][CH2:24][CH3:25])=[O:35])[cH:33][s:32]2)[CH2:12][CH:13]2[CH2:14][CH2:15][CH2:16][CH2:17]2)[cH:5][cH:6][cH:7]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 65578Oxalyl chlorideHCID 81531DiisopropylethylamineHCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 223153212-(3-Chloro-phenyl)-3-cyclopentyl-propionic acid

Product 1

HCID 23394572{2-[2-(3-Chloro-phenyl)-3-cyclopentyl-propionylamino]-thiazol-4-yl}-acetic acid ethyl ester

Sources & evidence

ORD record
ord-c0862847c8bf454fbc33f62367fe2cbe
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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