Hydrogen Peroxide → HCID 69237532, compound

HRID 1510212Notes

Reaction equation

HRID 1510212 reaction equation
[BH4-].[Na+].[C:3]([O:6][C@H:7]([C:31]1[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=1)[CH2:8][N:9]1[CH2:14][CH2:13][C:12]([CH2:15][CH2:16][O:17][CH:18]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:11][CH2:10]1)(=[O:5])[CH3:4].[OH-:38].[Na+].OO>C(O)C.O.C1COCC1>[C:3]([O:6][C@H:7]([C:31]1[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=1)[CH2:8][N:9]1[CH2:14][CH2:13][CH:12]([CH2:15][CH2:16][O:17][CH:18]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:11]([OH:38])[CH2:10]1)(=[O:5])[CH3:4]

Participants

8

Reactant 4

HCID 784Hydrogen PeroxideHCID 14798Sodium HydroxideHCID 4311764Sodium borohydrideHCID 69228053HCID 69228053, compound

Product 1

HCID 69237532HCID 69237532, compound

Reagents, catalysts & solvents 3

HCID 702EthanolSolventHCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

With reference to FIG. 8, general procedure II was used. The quantities of the chemicals in order of addition are as follows: NaBH4 (0.029 g, 0.762 mmol), THF (10 ml), BF3-ether complex (0.1 ml, 0.81 mmol), (R)-2-(4-(2-(benzhydryloxy)ethyl)-5,6-dihydropyridin-1(2H)-yl)-1-(4-fluorophenyl)ethyl acetate 7c (0.180 g, 0.38 mmol), water (0.3 ml), ethanol (0.4 ml), 3N NaOH (0.3 ml) and 30% H2O2 (0.2 ml, 1.9 mmol).

Workup

  1. additionThe quantities of the chemicals in order of addition

Sources & evidence

ORD record
ord-9e415b8d8fc24f4d91f943804c6e907b
Source dataset
uspto-grants-2012_07
Patent number
US08211916B2

Reaction notes

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