反应详情

To a solution of 4-fluoro-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylic acid (19 mg, 0.07 mmol), (1S,3R)-3-aminocyclohexanol (9.3 mg, 0.081 mmol), 1-hydroxybenzotriazole hydrate (9.0 mg, 0.07 mmol), and triethylamine (10 μL, 0.07 mmol) in tetrahydrofuran (1 mL) was added N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (15 mg. 0.081 mmol). After stirring overnight, the volatiles were removed in vacuo and the compound was purified by silica gel chromatography eluting with 5% methanol in dichloromethane to afford the title compound: (12.1 mg, 0.03 mmol). MS (ESI) m/z (M+H+): 373.2.

1. customthe volatiles were removed in vacuo
2. customthe compound was purified by silica gel chromatography
3. washeluting with 5% methanol in dichloromethane