HRID1510807

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID5234

Sodium chloride

ClNa

HCID7914

Isopropyl ether

C6H14O

$结构：CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(CSC(=O)c3ccco3)CS[C@H]12)c1csc(N)n1.[Na+]$

HCID23671563

Ceftiofur sodium salt

C19H16N5NaO7S3

PRODUCTS

生成物

$结构：CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(CSC(=O)c3ccco3)CS[C@H]12)c1csc(N)n1.Cl$

HCID9937686

Ceftiofur hydrochloride

C19H18ClN5O7S3

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

To a suspension of crystalline Ceftiofur sodium (10 g) in water (30 ml) was added THF (87 ml) at 10-30° C. To that sodium chloride (14 g) was added. pH of the solution was adjusted to 2.5-3.5. Organic layer pH was adjusted to 0.5-1.5 using conc. HCl. Addition of diisopropyl ether followed by filtration yielded pure title compound.]

WORKUP

后处理

filtrationfollowed by filtration