反应详情

The compound (23) (40.0 g) and acetic acid (100 ml) were put in a reaction vessel under a nitrogen atmosphere, and hydrogen peroxide (31% aqueous solution; 40.4 ml) was added dropwise in the temperature range of 25° C. to 30° C., and the stirring was continued for another 2 hours. Then the reaction mixture was poured into a vessel containing sodium hydrogen sulfite solution (100 ml) and ethyl acetate (300 ml), and mixed. Then the mixture was allowed to separate into organic and aqueous phases, and the extraction was carried out. The organic phase obtained was washed sequentially with water and brine, and dried over anhydrous magnesium sulfate. Then the solvent was distilled off under reduced pressure, giving 31.7 g of 4-butoxy-2,3-difluorophenol (24). The yield based on the compound (23) was 90.2%.

1. additionThen the reaction mixture was poured into a vessel
2. additionmixed
3. customto separate into organic and aqueous phases
4. extractionthe extraction
5. customThe organic phase obtained
6. washwas washed sequentially with water and brine
7. dry with materialdried over anhydrous magnesium sulfate
8. distillationThen the solvent was distilled off under reduced pressure