反应详情

A mixture of 6-hydroxy-1-naphthalenecarboxylic acid, methyl ester (1.01 g, 5 mmol), triethylamine (1.55 mL, 6 mmol) and N,N-dimethyl-4-pyridineamine (0.30 g, 2.5 mmol) in CH2Cl2 (25 mL) is treated with a solution of chloro(1,1-dimethylethyl)diphenylsilane (1.55 mL, 6 mmol) in CH2Cl2 (10 mL) and stirred at room temperature overnight. The mixture is washed with saturated aqueous NaHCO3, dried (Na2SO4) and solvent is evaporated off under reduced pressure to give a residue, which is purified by column chromatography (SiO2; hexane/CH2Cl2 1:1) to afford the title compound as an oil.

1. washThe mixture is washed with saturated aqueous NaHCO3
2. dry with materialdried (Na2SO4) and solvent
3. customis evaporated off under reduced pressure
4. customto give a residue, which
5. customis purified by column chromatography (SiO2; hexane/CH2Cl2 1:1)