反应详情

温度

50 °C

18.5 mg (0.75 mmol) of lithium hydroxide are added to a solution of 150 mg (0.26 mmol) of methyl 4-[(4E)-3-{2-[4-(methoxycarbonyl)phenyl]ethyl}-5-{2-[3-(2-oxopyrrolidin-1-yl)propoxy]-phenyl}pent-4-en-1-yl]benzoate in 10 ml of THF and 10 ml of water, and the mixture is stirred at 50° C. for 12 h. The mixture is then adjusted to pH 2 using 1 M hydrochloric acid and concentrated. The residue obtained is purified directly by preparative HPLC. This gives 104 mg (content 97%, 0.18 mmol, 71% of theory) of the title compound.

1. concentrationconcentrated
2. customThe residue obtained
3. customis purified directly by preparative HPLC