Methanol → HCID 57860637, compound

HRID 1513613Notes

Reaction equation

HRID 1513613 reaction equation
C([O:4][CH2:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]([C:17]2[N:29]([CH3:30])[C:28]3[C:27]4[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=4[N:21]([CH2:31][C:32]4[C:33]([CH3:42])=[N:34][C:35]([C:38]([F:41])([F:40])[F:39])=[CH:36][CH:37]=4)[C:20](=[O:43])[C:19]=3[C:18]=2[O:44][CH3:45])=[O:16])[CH2:10][CH2:9]1)=[O:7])(=O)C.C(=O)([O-])[O-].[K+].[K+].CO.O>C1COCC1.C(=O)([O-])O.[Na+]>[OH:4][CH2:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]([C:17]2[N:29]([CH3:30])[C:28]3[C:27]4[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=4[N:21]([CH2:31][C:32]4[C:33]([CH3:42])=[N:34][C:35]([C:38]([F:39])([F:40])[F:41])=[CH:36][CH:37]=4)[C:20](=[O:43])[C:19]=3[C:18]=2[O:44][CH3:45])=[O:16])[CH2:10][CH2:9]1)=[O:7]

Participants

7

Reactant 4

HCID 887MethanolHCID 962WaterHCID 11430Potassium CarbonateHCID 66893212HCID 66893212, compound

Product 1

HCID 57860637HCID 57860637, compoundYield 40.7%

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 516892Sodium BicarbonateSolvent

Procedure

A solution of 2-(4-{[(3-methoxy-1-methyl-5-{[2-methyl-6-(trifluoromethyl)pyridin-3-yl]methyl}-4-oxo-4,5-dihydro-1H-pyrrolo[3,2-c]quinolin-2-yl)carbonyl]amino}piperidin-1-yl)-2-oxoethyl acetate (50 mg) and potassium carbonate (55 mg, 0.40 mmol) in THF (2 mL)-methanol (1 mL)-water (1 mL) was stirred at room temperature for 3 hr. The reaction mixture was diluted with saturated sodium hydrogen carbonate solution, and extracted twice with ethyl acetate. The extract was washed with brine, dried over magnesium sulfate, and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate-hexane to give the title compound (19 mg, 5%) as white crystals.

Workup

  1. extractionextracted twice with ethyl acetate
  2. washThe extract was washed with brine
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under reduced pressure
  5. customThe residue was recrystallized from ethyl acetate-hexane

Sources & evidence

ORD record
ord-5735df1587cf40c199f454d27af59a3d
Source dataset
uspto-grants-2012_07
Patent number
US08217176B2

Reaction notes

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