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4-Iodo-2-methylsulfanyl-pyrimidine (1 g, 3.97 mmol) was dissolved in dry and degassed THF (9 ml). Pd(dba)2 (114 mg, 0.20 mmol) and tri(2-furyl)phosphine (50 mg, 0.20 mmol) were added. The mixture was cooled at 0° C. and then a 0.5 M solution of 6-methyl-2-pyridylzinc bromide in THF (13 ml, 6.5 mmol) was slowly added dropwise. After stirring the mixture at room temperature for 3 hours, ethyl acetate was added and the mixture was washed with water. The organic phase was dried (Na2SO4) and evaporated. The residue was purified by flash chromatography DCM-MeOH—NH4OH (20-0.1-0.1) to give 785 mg of the title compound (90% yield).

1. customin dry
2. customdegassed THF (9 ml)
3. washthe mixture was washed with water
4. dry with materialThe organic phase was dried (Na2SO4)
5. customevaporated
6. customThe residue was purified by flash chromatography DCM-MeOH—NH4OH (20-0.1-0.1)