Hydrochloric Acid → HCID 178500867, compound

HRID 1515272Notes

Reaction equation

HRID 1515272 reaction equation
[CH3:1][O:2][C:3](=[O:7])[CH2:4][C:5]#[N:6].[OH:8][NH2:9].Cl>C1COCC1>[CH3:1][O:2][C:3](=[O:7])[CH2:4][C:5](=[NH:6])[NH:9][OH:8]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 787HydroxylamineHCID 7747Methyl cyanoacetate

Product 1

HCID 178500867HCID 178500867, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2-Cyano-acetic acid methyl ester (990 mg, 10 mmol) was dissolved in THF (30 mL). Hydroxy amine (690 mg, HCl salt, 10 mmol) was added thereto, and the mixture was stirred for 2 h at 80°. After completion of the reaction, 1N HCl was added. The reaction mixture was extracted with EtOAc, and dried over MgSO4. The solvent was removed under reduced pressure, and the residue was used in the next reaction without further purification.

Workup

  1. additionwas added
  2. extractionThe reaction mixture was extracted with EtOAc
  3. dry with materialdried over MgSO4
  4. customThe solvent was removed under reduced pressure
  5. customthe residue was used in the next reaction without further purification

Sources & evidence

ORD record
ord-e6e6b95f2b96460499c77b9463406ff0
Source dataset
uspto-grants-2012_07
Patent number
US08222414B2

Reaction notes

Loading…