Diethylamine → HCID 25270558, compound

HRID 1516407Notes

Reaction equation

HRID 1516407 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]([C:11]2[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=2[NH:18][C:19]([C:21]2[CH:26]=[CH:25][C:24]([S:27]([CH3:33])(=[N:29][CH2:30][CH2:31]Br)=[O:28])=[CH:23][CH:22]=2)=[O:20])=[O:10])=[N:6][CH:7]=1.[CH2:34]([NH:36][CH2:37][CH3:38])[CH3:35]>CN(C=O)C.O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]([C:11]2[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=2[NH:18][C:19]([C:21]2[CH:26]=[CH:25][C:24]([S:27]([CH3:33])(=[N:29][CH2:30][CH2:31][N:36]([CH2:37][CH3:38])[CH2:34][CH3:35])=[O:28])=[CH:23][CH:22]=2)=[O:20])=[O:10])=[N:6][CH:7]=1

Participants

5

Reactant 2

HCID 8021DiethylamineHCID 71540230HCID 71540230, compound

Product 1

HCID 25270558HCID 25270558, compoundYield 60%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

To a stirring solution of S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-[2-bromo-ethyl]sulfoximide (150 mg, 0.00026 mol) in DMF(0.7 mL) was added diethyl amine (1 mL) at 25° C. Reaction mixture was stirred at same temperature for 2 hr. Reaction mixture was diluted with water and filtered. Drying afforded 85 mg of titled compound in 60% yield.

Workup

  1. customReaction mixture
  2. customReaction mixture
  3. filtrationfiltered
  4. customDrying

Sources & evidence

ORD record
ord-c6932a2446654a0fb0dc365735d6df7b
Source dataset
uspto-grants-2012_07
Patent number
US08227492B2

Reaction notes

Loading…