Triethylamine → HCID 49848904, compound

HRID 1517337Notes

Reaction equation

HRID 1517337 reaction equation
[CH3:1][C:2]1[C:3]([O:21][CH:22]2[CH2:27][CH2:26][N:25]([C:28]([O:30][C:31](C)([CH3:33])[CH3:32])=[O:29])[CH2:24][CH2:23]2)=[N:4][CH:5]=[N:6][C:7]=1[N:8]1[C:16]2[C:11](=[CH:12][C:13]([S:17]([CH3:20])(=[O:19])=[O:18])=[CH:14][CH:15]=2)[CH2:10][CH2:9]1.[CH2:35](N(CC)CC)C>>[CH:16]([N:8]([CH:7]([CH3:2])[CH3:35])[CH2:9][CH3:10])([CH3:15])[CH3:11].[CH3:1][C:2]1[C:3]([O:21][CH:22]2[CH2:27][CH2:26][N:25]([C:28]([O:30][CH:31]([CH3:33])[CH3:32])=[O:29])[CH2:24][CH2:23]2)=[N:4][CH:5]=[N:6][C:7]=1[N:8]1[C:16]2[C:11](=[CH:12][C:13]([S:17]([CH3:20])(=[O:18])=[O:19])=[CH:14][CH:15]=2)[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 68561749HCID 68561749, compound

Product 2

HCID 81531DiisopropylethylamineHCID 49848904HCID 49848904, compoundYield 88%

Procedure

The same reaction as in the method described in Example 2 was performed using the tert-butyl 4-({5-methyl-6-[5-(methylsulfonyl)indolin-1-yl]pyrimidin-4-yl}oxy)piperidine-1-carboxylate (208 mg, 0.426 mmol) produced in Example 26 and, instead of triethylamine, diisopropylethylamine (380 μL, 2.13 mmol) to obtain the title compound as white foam (177 mg, yield: 88%).

Workup

  1. customThe same reaction as in the method

Sources & evidence

ORD record
ord-5a0f8b918259455192bbc9934e405871
Source dataset
uspto-grants-2012_07
Patent number
US08232287B2

Reaction notes

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