HCID 86641267, compound → HCID 46196135, compound

HRID 1517552Notes

Reaction equation

HRID 1517552 reaction equation
[CH2:1]([C:4]1[C:13]([O:14][CH3:15])=[C:12]([C:16]([CH3:19])([CH3:18])[CH3:17])[CH:11]=[C:10]([C:20]2[C:21]([O:26]CC3C=CC=CC=3)=[N:22][CH:23]=[CH:24][CH:25]=2)[C:5]=1[C:6]([O:8][CH3:9])=[O:7])[CH:2]=[CH2:3]>CCOC(C)=O.[OH-].[OH-].[Pd+2]>[CH3:9][O:8][C:6](=[O:7])[C:5]1[C:10]([C:20]2[C:21](=[O:26])[NH:22][CH:23]=[CH:24][CH:25]=2)=[CH:11][C:12]([C:16]([CH3:17])([CH3:18])[CH3:19])=[C:13]([O:14][CH3:15])[C:4]=1[CH2:1][CH2:2][CH3:3]

Participants

4

Reactant 1

HCID 86641267HCID 86641267, compound

Product 1

HCID 46196135HCID 46196135, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 8857Ethyl AcetateSolvent

Procedure

step 7—A mixture of 128 (17 mg) and Pd(OH)2/C (20 mg) in EtOAc (10 mL) was stirred under 1 atm H2 for 30 min then the catalyst was filtered off. The filtrate was concentrated to afford 4.9 mg of I-90 as a waxy solid.

Workup

  1. filtrationthe catalyst was filtered off
  2. concentrationThe filtrate was concentrated
  3. customto afford 4.9 mg of I-90 as a waxy solid

Sources & evidence

ORD record
ord-3df041ff62b841f9943fe1ccd5040199
Source dataset
uspto-grants-2012_07
Patent number
US08232271B2

Reaction notes

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