反应详情

To a mixture of 1-((tetrahydro-2H-pyran-2-yloxy)methyl)cyclopropanol (1.6 g, 9.3 mmol) and benzoic acid (1.25 g, 11.16 mmol, Shanghai Haiqu chemical Ltd.) in 50 mL of CH2Cl2 was added DMAP (227 mg, 1.86 mmol, Shanghai Haiqu chemical Ltd.) and EDCI (2.73 g, 14.25 mmol, Shanghai Haiqu chemical Ltd.) at rt. The reaction mixture was stirred at rt overnight, then concentrated and purified by a silica gel column chromatography (20:1 (v/v) petroleum ether/EtOAc)) to afford the title compound as colorless oil (1.8 g, 70%).

1. concentrationconcentrated
2. custompurified by a silica gel column chromatography (20:1 (v/v) petroleum ether/EtOAc))