反应详情

To a solution of allyl-{2-[4-(4-isopropyl-benzenesulfonylamino)-phenyl]-ethyl}-carbamic acid tert-butyl ester (200 mg, 0.44 mmol) in DMF (5 ml), 15-crown-5, and sodium hydride (20 mg, 0.48 mmol) were added, and the mixture was stirred at room temperature for 30 min. Methyliodide (60 mg, 0.44 mmol) was added and the mixture was stirred for 3 h at room temperature. After concentration in vacuo the residue was partitioned between dichloromethane and saturated aqueous NaHCO3. The organic layer was washed with water, dried over MgSO4, filtered and the solvent evaporated under reduced pressure to give the product as a yellow oil (200 mg, 97%).

1. stirringthe mixture was stirred for 3 h at room temperature
2. concentrationAfter concentration in vacuo the residue
3. customwas partitioned between dichloromethane and saturated aqueous NaHCO3
4. washThe organic layer was washed with water
5. dry with materialdried over MgSO4
6. filtrationfiltered
7. customthe solvent evaporated under reduced pressure