反应详情

A mixture of compound 94B (8.0 g, 14.15 mmol), dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine (1.162 g, 2.83 mmol) and palladium acetate (0.318 g, 1.415 mmol) in THF (60 mL) was stirred at room temperature for 5 min. To this solution was added 0.5 M (2-(1,3-dioxolan-2-yl)ethyl)zinc(II) bromide (56.6 mL, 28.3 mmol) via an additional funnel drop wise at room temperature. The reaction was stirred overnight. The solvent was removed, and residue was loaded on a silica column and eluted with 7:3/hexanes: EtOAc to give 7.58 g of desired product 96A: APCI (+)LC/MS: 587 (M+H)+.

1. stirringThe reaction was stirred overnight
2. customThe solvent was removed
3. washeluted with 7:3/hexanes