Hydrochloric Acid → Benzyl 3-amino-6-chloro-2-fluorobenzoate

HRID 152201Notes

Reaction equation

HRID 152201 reaction equation
[CH2:10]([Li:11])[CH2:12][CH2:13][CH3:14].[Cl:15][Si:16]([CH3:17])([CH3:18])[CH2:19][CH2:20][Si:21]([Cl:22])([CH3:23])[CH3:24].[Cl:1][c:2]1[cH:3][c:4]([F:9])[c:5]([NH2:8])[cH:6][cH:7]1.[Cl:25][C:26](=[O:27])[O:28][CH2:29][c:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1.[ClH:36].[O:37]1[CH2:38][CH2:39][CH2:40][CH2:41]1.[OH2:42]>>[Cl:1][c:2]1[c:3]([C:26](=[O:27])[O:28][CH2:29][c:30]2[cH:31][cH:32][cH:33][cH:34][cH:35]2)[c:4]([F:9])[c:5]([NH2:8])[cH:6][cH:7]1

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 962WaterHCID 8028TetrahydrofuranHCID 10387Benzyl chloroformateHCID 835521,2-Bis(chlorodimethylsilyl)ethaneHCID 938984-Chloro-2-fluoroanilineHCID 178418339Butyllithium

Product 1

HCID 58087305Benzyl 3-amino-6-chloro-2-fluorobenzoate

Sources & evidence

ORD record
ord-3afe3f5b1fbe4e18882376a3ddff1896
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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