Hydrochloric Acid → HCID 90412134, compound

HRID 1522026Notes

Reaction equation

HRID 1522026 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:32][CH3:33])=[C:6]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]3[NH:14][C:15]([C:17]4[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[C:19]([CH3:31])([CH3:30])[CH:18]=4)=[CH:16][C:9]=23)[CH:7]=1.FC(F)(F)C(O)=O.Cl>ClCCl.CO.C(OCC)C>[CH3:30][C:19]1([CH3:31])[NH:20][CH2:21][CH2:22][C:17]([C:15]2[NH:14][C:10]3=[N:11][CH:12]=[CH:13][C:8]([C:6]4[CH:7]=[C:2]([F:1])[CH:3]=[CH:4][C:5]=4[O:32][CH3:33])=[C:9]3[CH:16]=2)=[CH:18]1

Participants

7

Reactant 3

HCID 313Hydrochloric AcidHCID 6422Trifluoroacetic acidHCID 90412527HCID 90412527, compound

Product 1

HCID 90412134HCID 90412134, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

A mixture of Example 271C (0.249 g, 0.551 mmol) and 2,2,2-trifluoroacetic acid (1 mL, 12.98 mmol) in dichloromethane (1 mL) was stirred for 24 hours at room temperature and concentrated. The hydrochloride salt was prepared by dissolving the resultant solid in methanol and adding 2M hydrogen chloride in diethyl ether. After concentrating under reduced pressure, the title compound was obtained. MS (ESI) m/e 352.1 (M+1)+.

Workup

  1. concentrationconcentrated
  2. concentrationAfter concentrating under reduced pressure

Sources & evidence

ORD record
ord-bd0300b0ede049ac82a224232059560d
Source dataset
uspto-grants-2015_07
Patent number
US09073922B2

Reaction notes

Loading…