HRID1522796

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6101

4-Methylbenzenesulfonic acid

C7H8O3S

结构：CCc1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1.O=C(O[C@@H](C(=O)O)[C@@H](OC(=O)c1ccccc1)C(=O)O)c1ccccc1

HCID86731963

未命名化合物

PRODUCTS

生成物

结构：CCc1ccc(CCOc2ccc(C[C@H]3SC(=O)NC3=O)cc2)nc1.Cc1ccc(S(=O)(=O)O)cc1

HCID86651734

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

To a solution of p-toluenesulphonic acid (0.8 g) in IPA (12 mL) at 40° C. was added R)-5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione (−)-O,O′-dibenzoyl-L-tartrate

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4f690bce795c443c8b1c33b7496dd9d2
来源数据集: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09078885B2
来源说明: uspto-grants-2015_07

反应 SMILES

[C:1]1([CH3:11])[CH:6]=[CH:5][C:4]([S:7]([OH:10])(=[O:9])=[O:8])=[CH:3][CH:2]=1.C(O[C@H]([C@H](C(O)=O)OC(=O)C1C=CC=CC=1)C(O)=O)(=O)C1C=CC=CC=1.[CH2:38]([C:40]1[CH:41]=[CH:42][C:43]([CH2:46][CH2:47][O:48][C:49]2[CH:62]=[CH:61][C:52]([CH2:53][CH:54]3[S:58][C:57](=[O:59])[NH:56][C:55]3=[O:60])=[CH:51][CH:50]=2)=[N:44][CH:45]=1)[CH3:39]>CC(O)C>[S:7]([C:4]1[CH:5]=[CH:6][C:1]([CH3:11])=[CH:2][CH:3]=1)([OH:10])(=[O:9])=[O:8].[CH2:38]([C:40]1[CH:41]=[CH:42][C:43]([CH2:46][CH2:47][O:48][C:49]2[CH:62]=[CH:61][C:52]([CH2:53][C@H:54]3[S:58][C:57](=[O:59])[NH:56][C:55]3=[O:60])=[CH:51][CH:50]=2)=[N:44][CH:45]=1)[CH3:39]