反应详情

Compound 22s was synthesised by essentially the same procedure as compound 18s (Example 16), using compound 48 (Example 7; 55 mg, 0.2 mmol), 3-chlorophenol (39 mg, 0.3 mmol), triphenylphosphine (78 mg, 0.3 mmol), DEAD (0.05 ml, 0.3 mmol), and THF (1 ml). The crude residue was purified twice by flash column chromatography (silica, DCM/MeOH 1:0 to 8:2) to afford the title compound as a colourless oil (51 mg; 65%). Analyses were performed on the free base, and the free base was converted to the HCl salt for testing.

1. customThe crude residue was purified twice by flash column chromatography (silica, DCM/MeOH 1:0 to 8:2)