反应详情

1-(3-Hydroxy-5-methoxyphenyl)ethanone (O3.033; 1.12 g) and 1-iodo-3,3-dimethylbutane (1.57 g) were dissolved in DMF, and sodium hydride (194 mg) was added. After stirring at RT for 2 h, the DMF was drawn off. The residue was taken up in EA, washed with water, dried, filtered and concentrated. The residue was purified using silica gel (40 g cartridge, n-heptane/EA 0-50% within 30 min). 850 mg of the title compound were obtained.

1. washwashed with water
2. customdried
3. filtrationfiltered
4. concentrationconcentrated
5. customThe residue was purified
6. customsilica gel (40 g cartridge, n-heptane/EA 0-50% within 30 min)