Hydroxyamine hydrochloride → HCID 89470836, compound

HRID 1525344Notes

Reaction equation

HRID 1525344 reaction equation
[CH:1]([C:3]1[CH:8]=[CH:7][C:6]([P:9]([CH3:14])(=[O:13])[O:10][CH2:11][CH3:12])=[CH:5][CH:4]=1)=O.Cl.[NH2:16][OH:17].C([O-])(O)=O.[Na+]>C(O)C>[OH:17]/[N:16]=[CH:1]/[C:3]1[CH:8]=[CH:7][C:6]([P:9]([CH3:14])(=[O:13])[O:10][CH2:11][CH3:12])=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium BicarbonateHCID 89462556HCID 89462556, compound

Product 1

HCID 89470836HCID 89470836, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of compound 38-c (530 mg, 2.5 mmol) in ethanol (10 mL) was added hydroxylamine hydrochloride (230 mg, 3.2 mmol) and NaHCO3 (360 g, 3.60 mmol). The reaction mixture was then stirred for 10 h at room temperature. The resulting mixture was concentrated under reduce pressure to afford crude compound 38-d (570 mg). LC-MS 228 [M+H]+

Workup

  1. concentrationThe resulting mixture was concentrated
  2. customto afford crude compound 38-d (570 mg)

Sources & evidence

ORD record
ord-fc9c2a1c6d9443fbaf6315791720bdf5
Source dataset
uspto-grants-2015_07
Patent number
US09079930B2

Reaction notes

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