Ethanol → HCID 117770079, compound

HRID 1526385Notes

Reaction equation

HRID 1526385 reaction equation
[C:1]([C:3]1[C:4](=[O:23])[N:5]([C:11]2[C:16]([F:17])=[CH:15][C:14]([NH:18][C:19](=O)[CH3:20])=[CH:13][C:12]=2[F:22])[CH:6]=[CH:7][C:8]=1OC)#[N:2].[OH2:24].[NH2:25][NH2:26].C(O)C>O1CCCC1>[NH2:2][C:1]1[C:3]2[C:4](=[O:23])[N:5]([C:11]3[C:12]([F:22])=[CH:13][C:14]([NH:18][C:19](=[O:24])[CH3:20])=[CH:15][C:16]=3[F:17])[CH:6]=[CH:7][C:8]=2[NH:26][N:25]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 24654Hydrazine hydrate (1:1)HCID 117770327HCID 117770327, compound

Product 1

HCID 117770079HCID 117770079, compoundYield 68.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of N-(4-(3-cyano-4-methoxy-2-oxopyridin-1(2H)-yl)-3,5-difluorophenyl)acetamide obtained in Step C (1.10 g), hydrazine monohydrate (0.52 g), ethanol (30 mL) and tetrahydrofuran (15 mL) was stirred at 60° C. for 2 hr. The solvent was evaporated under reduced pressure, and to the residue was added isopropyl ether, and the mixture was stirred for 15 min. The precipitate was collected by filtration to give the title compound (0.75 g).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. additionto the residue was added isopropyl ether
  3. stirringthe mixture was stirred for 15 min
  4. filtrationThe precipitate was collected by filtration

Sources & evidence

ORD record
ord-972f561c78c945948bc1438461ed936e
Source dataset
uspto-grants-2015_07
Patent number
US09085578B2

Reaction notes

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