Ethylamine hydrochloride → HCID 56644019, compound

HRID 1526693Notes

Reaction equation

HRID 1526693 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:14]3[CH:15]=[C:16]([C:19]4[CH:24]=[CH:23][C:22]([CH:25]=O)=[CH:21][CH:20]=4)[CH:17]=[CH:18][C:13]=3[N:12]3[C:27]([CH3:30])=[N:28][N:29]=[C:11]3[C@H:10]([CH2:31][C:32]([NH:34][CH2:35][CH3:36])=[O:33])[N:9]=2)=[CH:4][CH:3]=1.Cl.[CH2:38]([NH2:40])[CH3:39].C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].C(=O)([O-])O.[Na+]>C(Cl)Cl.C(O)(=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:14]3[CH:15]=[C:16]([C:19]4[CH:20]=[CH:21][C:22]([CH2:25][NH:40][CH2:38][CH3:39])=[CH:23][CH:24]=4)[CH:17]=[CH:18][C:13]=3[N:12]3[C:27]([CH3:30])=[N:28][N:29]=[C:11]3[C@H:10]([CH2:31][C:32]([NH:34][CH2:35][CH3:36])=[O:33])[N:9]=2)=[CH:4][CH:3]=1

Participants

7

Reactant 4

HCID 11198Ethylamine hydrochlorideHCID 516892Sodium BicarbonateHCID 5049666Sodium triacetoxyborohydrideHCID 86679716HCID 86679716, compound

Product 1

HCID 56644019HCID 56644019, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 6344DichloromethaneSolvent

Procedure

(S)-2-(6-(4-Chlorophenyl)-8-(4-formylphenyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide (for a preparation see Intermediate 6) (75 mg) was dissolved in DCM (5 ml). Ethylamine hydrochloride (18.42 mg) and acetic acid (8.62 μl) were added and the reaction mixture was stirred for 5 min. Sodium triacetoxyborohydride (160 mg) was added and the reaction mixture was stirred at room temperature, under nitrogen, over the weekend. Saturated sodium hydrogen carbonate solution (5 ml) was added and the reaction mixture was stirred for 10 min. The organic phase was separated and the saturated sodium hydrogen carbonate solution was extracted with DCM (10 ml). The DCM extracts were combined, dried and the solvent was evaporated. The residue was chromatographed (0-15% methanol:DCM), triturated with diethyl ether and dried in a vacuum dessicator at 40° C. overnight to give (S)-2-(6-(4-chlorophenyl)-8-(4-((ethylamino)methyl)phenyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide (28.7 mg) as a white solid. LCMS (formate): MH+ 527/529, RT 0.67 min

Workup

  1. stirringthe reaction mixture was stirred at room temperature, under nitrogen, over the weekend
  2. stirringthe reaction mixture was stirred for 10 min
  3. customThe organic phase was separated
  4. extractionthe saturated sodium hydrogen carbonate solution was extracted with DCM (10 ml)
  5. customdried
  6. customthe solvent was evaporated
  7. customThe residue was chromatographed (0-15% methanol:DCM)
  8. customtriturated with diethyl ether
  9. customdried in a vacuum dessicator at 40° C. overnight

Sources & evidence

ORD record
ord-74c471c9e42f4d9cbc8c9000371be84e
Source dataset
uspto-grants-2015_07
Patent number
US09085582B2

Reaction notes

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