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HRID1527505

反应详情

EQUATION

反应方程式

HRID 1527505 的结构方程式

REACTANTS

反应物

4
结构：CN
HCID6329

Methylamine

CH5N

结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F
HCID9886157

Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

C10H15F6N6OP

结构：CC(C)(C)OC(=O)NCc1cc(C(=O)O)cc(Cl)c1F
HCID68283414

未命名化合物

PRODUCTS

生成物

1
结构：CNC(=O)c1cc(Cl)c(F)c(CNC(=O)OC(C)(C)C)c1
HCID68283777

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

was prepared according to Scheme C3 (step A) from 3-(tert-butoxycarbonylamino-methyl)-5-chloro-4-fluoro-benzoic acid (125 mg, 0.41 mmol), HATU (235 mg, 0.6 mmol), methylamine (0.25 mL, 2M in THF) and DIPEA (0.29 mL, 1.6 mmol) in DMF (2 mL). MS (LC-MS): 633.0 [2M]+; tR (HPLC conditions c): 4.55 min.

WORKUP

后处理

  1. customwas prepared
  2. custom4.55 min.