反应详情

温度

100 °C

A mixture of 2.42 g of 2,6-dimethylaniline, 7.35 g of hexafluoroacetone hydrate, and 0.04 g of p-toluenesulfonic acid monohydrate was stirred under heating at 100° C. for 5 hours. After the temperature was returned to room temperature, the mixture was diluted with ethyl acetate and washed with a 1N sodium hydroxide aqueous solution. Then, the solvent was distilled off under reduced pressure, and the precipitated crude crystals were washed with a n-hexane-ethyl acetate mixed solvent to obtain 4.47 g (yield 78%) of the title compound as a solid.

1. customwas returned to room temperature
2. washwashed with a 1N sodium hydroxide aqueous solution
3. distillationThen, the solvent was distilled off under reduced pressure
4. customthe precipitated crude crystals
5. washwere washed with a n-hexane-ethyl acetate mixed solvent