Triethylamine → HCID 57519920, compound
Reaction equation
ClC(O[C:6](=[O:12])OC(Cl)(Cl)Cl)(Cl)Cl.[F:13][C:14]([F:23])([F:22])[C:15]1[N:20]=[C:19]([NH2:21])[CH:18]=[CH:17][CH:16]=1.C(N(CC)CC)C.[Br:31][C:32]1[CH:33]=[C:34]2[C:39](=[CH:40][CH:41]=1)[N:38]=[CH:37][CH:36]=[C:35]2[NH2:42]>C(Cl)Cl>[Br:31][C:32]1[CH:33]=[C:34]2[C:39](=[CH:40][CH:41]=1)[N:38]=[CH:37][CH:36]=[C:35]2[NH:42][C:6]([NH:21][C:19]1[CH:18]=[CH:17][CH:16]=[C:15]([C:14]([F:13])([F:22])[F:23])[N:20]=1)=[O:12]Participants
Conditions
- Temperature
- 0 °C
Procedure
366 mg of bis(trichloromethyl)carbonate (1.234 mmol) were dissolved in 7 ml of DCM and cooled to 0° C. To this mixture the solution of 400 mg of 6-(trifluoromethyl)pyridin-2-amine (2.467 mmol) and 379 μl of triethylamine (5.43 mmol) in 9.7 ml DCM was slowly added over 60 minutes at 0° C., and stirring was continued for an additional 60 minutes at room temperature. 550 mg of 6-bromoquinolin-4-amine (2.467 mmol) and 379 μl of triethylamine (5.43 mmol) were suspended in 9.7 ml and subsequently slowly added to the reaction mixture at RT, which became a clear solution after 45 minutes. After stirring over night the reaction mixture was poured into ice water and stirred for 2 h. The precipitation formed was filtered off and dried in vacuum for 24 h. 810 mg of the desired product were obtained as an off white powder (yield: 80%). The quite pure raw material was used without further purification in the next step.
Workup
- additionsubsequently slowly added to the reaction mixture at RT
- customafter 45 minutes
- stirringAfter stirring over night the reaction mixture
- stirringstirred for 2 h
- customThe precipitation
- customformed
- filtrationwas filtered off
- customdried in vacuum for 24 h
Sources & evidence
- ORD record
- ord-75cbc8e726af4a1ca4d5fc7b3a9538d9
- Source dataset
- uspto-grants-2015_07
- Patent number
- US09090592B2
Reaction notes
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