Triethylamine → HCID 178512739, compound

HRID 1529159Notes

Reaction equation

HRID 1529159 reaction equation
C(O)(=O)C.[F:5][C:6]([F:25])([C:21]([F:24])([F:23])[F:22])[CH2:7][CH2:8][N:9]1[C:13]2=[N:14][CH:15]=[CH:16][CH:17]=[C:12]2[C:11]([C:18](=[NH:20])[NH2:19])=[N:10]1.C([N:28](CC)CC)C.O.NN>C(O)C>[F:25][C:6]([F:5])([C:21]([F:22])([F:23])[F:24])[CH2:7][CH2:8][N:9]1[C:13]2=[N:14][CH:15]=[CH:16][CH:17]=[C:12]2[C:11]([C:18](=[NH:19])[NH:20][NH2:28])=[N:10]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 24654Hydrazine hydrate (1:1)HCID 86715165HCID 86715165, compound

Product 1

HCID 178512739HCID 178512739, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.6 g (about 1.144 mmol) of the compound from Example 13A were dissolved in ml of ethanol, and 462 mg (4.574 mmol) of triethylamine and 71 mg (1.144 mmol) of hydrazine hydrate (80% strength solution in water) were added at 0° C. The mixture was stirred at RT overnight and then concentrated on a rotary evaporator. This gave 689 mg (purity about 60%) of the title compound.

Workup

  1. additionwere added at 0° C
  2. concentrationconcentrated on a rotary evaporator

Sources & evidence

ORD record
ord-e39ea87d50a04278ae2613a495f3b8d0
Source dataset
uspto-grants-2015_07
Patent number
US09090610B2

Reaction notes

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