Triethylamine → HCID 178512740, compound

HRID 1529160Notes

Reaction equation

HRID 1529160 reaction equation
C(O)(=O)C.[F:5][C:6]1[CH:7]=[C:8]2[C:14]([C:15](=[NH:17])[NH2:16])=[N:13][N:12]([CH2:18][CH2:19][C:20]([F:26])([F:25])[C:21]([F:24])([F:23])[F:22])[C:9]2=[N:10][CH:11]=1.C([N:29](CC)CC)C.O.NN>C(O)C>[F:5][C:6]1[CH:7]=[C:8]2[C:14]([C:15](=[NH:16])[NH:17][NH2:29])=[N:13][N:12]([CH2:18][CH2:19][C:20]([F:26])([F:25])[C:21]([F:23])([F:24])[F:22])[C:9]2=[N:10][CH:11]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 24654Hydrazine hydrate (1:1)HCID 86715167HCID 86715167, compound

Product 1

HCID 178512740HCID 178512740, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.62 g (0.901 mmol) of the compound from Example 9A (purity about 56%) were dissolved in 10.3 ml of ethanol, and 456 mg (4.506 mmol) of triethylamine and 70 mg (1.126 mmol) of hydrazine hydrate (80% strength solution in water) were added at 0° C. The mixture was stirred at RT overnight and then concentrated on a rotary evaporator. This gave a crude compound which was directly reacted further.

Workup

  1. concentrationconcentrated on a rotary evaporator

Sources & evidence

ORD record
ord-86cca9009ccb48e1b14f6e3aceddfd30
Source dataset
uspto-grants-2015_07
Patent number
US09090610B2

Reaction notes

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