反应详情

The title compound is synthesized according to general procedure GP5 starting from 100 mg (0.28 mmol) 4-[3-(6-Amino-pyridin-3-ylethynyl)-2-ethyl-pyridin-4-yl]-2-fluoro-benzoic acid (A-38) using 29 mg (0.33 mmoL) piperazine, 116 mg (0.30 mmol) HATU and 81 μL DIPEA in 1 mL DMF. After completion of the reaction, the reaction mixture is filtered and the product is isolated from the obtained solution by RP-HPLC using a H2O/MeOH-gradient. Yield: 8 mg (6%).

1. customAfter completion of the reaction
2. filtrationthe reaction mixture is filtered
3. customthe product is isolated from the obtained solution by RP-HPLC