反应详情

温度

45 °C

To a solution of 4-bromo-pyridine-3-carbaldehyde (1.50 g, 8.06 mmol) in DMF (10 mL) and water (1 mL) was added K2CO3 (1.34 g, 9.68 mmol) and methyl thioglycolate (0.87 mL, 9.68 mmol). The mixture was heated at 45° C. for 18 hours. The reaction mixture was removed from the heating bath and diluted with water (50 mL). After 1 hour, the fluffy solid that formed was filtered and washed with water. The material thus obtained was dried in a 60° C. vacuum oven to a constant weight of 0.92 g (59%). MS m/z 194 (M+H)+.

1. customThe reaction mixture was removed from the heating bath
2. additiondiluted with water (50 mL)
3. customthe fluffy solid that formed
4. filtrationwas filtered
5. washwashed with water
6. customThe material thus obtained
7. customwas dried in a 60° C. vacuum oven to a constant weight of 0.92 g (59%)