Diisopropylethylamine → 2-(2-Isopropyl-5-methyl-2H-[1,2,4]triazol-3-yl)-9-(1-isopropylpiperidin-4-ylsulfanyl)-8-methyl-4,5-dihydro-6-oxa-1,3a-diazabenzo[e]azulene

HRID 1530407Notes

Reaction equation

HRID 1530407 reaction equation
Br[C:2]1[C:3]([CH3:25])=[CH:4][C:5]2[O:14][CH2:13][CH2:12][N:11]3[C:7](=[N:8][C:9]([C:15]4[N:16]([CH:21]([CH3:23])[CH3:22])[N:17]=[C:18]([CH3:20])[N:19]=4)=[CH:10]3)[C:6]=2[CH:24]=1.[CH:26]([N:29]1[CH2:34][CH2:33][CH:32]([SH:35])[CH2:31][CH2:30]1)([CH3:28])[CH3:27].CC1(C)C2C(=C(P(C3C=CC=CC=3)C3C=CC=CC=3)C=CC=2)OC2C(P(C3C=CC=CC=3)C3C=CC=CC=3)=CC=CC1=2.CCN(C(C)C)C(C)C>O1CCOCC1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[CH:21]([N:16]1[C:15]([C:9]2[N:8]=[C:7]3[N:11]([CH2:12][CH2:13][O:14][C:5]4[CH:4]=[C:3]([CH3:25])[C:2]([S:35][CH:32]5[CH2:33][CH2:34][N:29]([CH:26]([CH3:28])[CH3:27])[CH2:30][CH2:31]5)=[CH:24][C:6]=43)[CH:10]=2)=[N:19][C:18]([CH3:20])=[N:17]1)([CH3:23])[CH3:22]

Participants

7

Reactant 4

HCID 81531DiisopropylethylamineHCID 6360441,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)HCID 199366054-Piperidinethiol, 1-(1-methylethyl)-HCID 683128519-Bromo-2-(2-isopropyl-5-methyl-2H-[1,2,4]triazol-3-yl)-8-methyl-4,5-dihydro-6-oxa-1,3a-diazabenzo[e]azulene

Product 1

HCID 683132282-(2-Isopropyl-5-methyl-2H-[1,2,4]triazol-3-yl)-9-(1-isopropylpiperidin-4-ylsulfanyl)-8-methyl-4,5-dihydro-6-oxa-1,3a-diazabenzo[e]azuleneYield 64.2%

Reagents, catalysts & solvents 2

HCID 9811564Bis(dibenzylideneacetone)palladiumCatalystHCID 312751,4-DioxaneSolvent

Conditions

Temperature
120 °C

Procedure

A mixture of 9-bromo-2-(2-isopropyl-5-methyl-2H-[1,2,4]triazol-3-yl)-8-methyl-4,5-dihydro-6-oxa-1,3a-diazabenzo[e]azulene (146 mg, 0.363 mmol), 1-isopropylpiperidine-4-thiol (87 mg, 0.545 mmol), Pd2(dba)3 (17 mg, 5 mol %), XantPhos (21 mg, 10 mol %) and DIPEA (254 μl, 1.45 mmol) in dioxane (4 mL) was purged with nitrogen and then heated at 120° C. for 2 h using microwave irradiation. The reaction mixture was then diluted with DCM (80 mL) and purified by column chromatography (Si-PCC, gradient 0-8% 2M NH3/MeOH in DCM) followed by (C18, gradient 20-55% MeOH in 0.5% TFA/H2O). The product containing fractions were combined and concentrated in vacuo. The resulting residue was loaded onto an Isolute® SCX-2 cartridge which was washed with MeOH and the product eluted with 0.5M NH3/MeOH. The basic fractions were concentrated under reduced pressure affording 2-(2-Isopropyl-5-methyl-2H-[1,2,4]triazol-3-yl)-9-(1-isopropylpiperidin-4-ylsulfanyl)-8-methyl-4,5-dihydro-6-oxa-1,3a-diazabenzo[e]azulene as a colorless solid (112 mg, 64%). LCMS: RT 2.23 and 2.28 min [M+H]+ 480.9

Workup

  1. customwas purged with nitrogen
  2. custommicrowave irradiation
  3. additionThe reaction mixture was then diluted with DCM (80 mL)
  4. custompurified by column chromatography (Si-PCC, gradient 0-8% 2M NH3/MeOH in DCM)
  5. additionThe product containing fractions
  6. concentrationconcentrated in vacuo
  7. washwas washed with MeOH
  8. washthe product eluted with 0.5M NH3/MeOH
  9. concentrationThe basic fractions were concentrated under reduced pressure

Sources & evidence

ORD record
ord-0939d17995ee4194b64544a1020fe573
Source dataset
uspto-grants-2015_07
Patent number
US09090628B2

Reaction notes

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