Hydrochloric Acid → L-Ascorbic Acid

HRID 1531426Notes

Reaction equation

HRID 1531426 reaction equation
C(O)C.[Na].[CH2:5]([OH:17])[C@H:6]([OH:16])[C@@H:7](O)[C@H:8]([OH:14])[C:9]([C:11]([OH:13])=[O:12])=[O:10].Cl>CC(C)=O>[O:12]=[C:11]1[O:13][C@H:7]([C@H:6]([CH2:5][OH:17])[OH:16])[C:8]([OH:14])=[C:9]1[OH:10]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 1024242-keto-L-Gulonic acidHCID 5360545Sodium

Product 1

HCID 54670067L-Ascorbic Acid

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

JP-A 58-177986 describes a process which comprises the addition of ethanol and acetone to the sodium salt of 2-keto-L-gulonic acid, neutralization with hydrochloric acid, the removal of the precipitated sodium chloride by filtration and then the maintenance of the reaction mixture at temperatures in the range from 25° C. to 75° C., by means of which L-ascorbic acid is obtained.

Workup

  1. customthe removal of the precipitated sodium chloride
  2. filtrationby filtration

Sources & evidence

ORD record
ord-0ca163de46b5418fa6b99baa9454f9bc
Source dataset
uspto-grants-2001_03
Patent number
US06197977B1

Reaction notes

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