Potassium Carbonate → HCID 21254039, compound

HRID 1531445Notes

Reaction equation

HRID 1531445 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]([Cl:11])[C:8]([C:12]2[C:16]([F:17])=[C:15]([O:18][CH:19]([F:21])[F:20])[N:14]([CH3:22])[N:13]=2)=[CH:7][C:3]=1[C:4](Cl)=[O:5].C(=O)([O-])[O-].[K+].[K+].Cl.[CH3:30][O:31][NH2:32]>>[CH3:30][O:31][NH:32][C:4](=[O:5])[C:3]1[CH:7]=[C:8]([C:12]2[C:16]([F:17])=[C:15]([O:18][CH:19]([F:21])[F:20])[N:14]([CH3:22])[N:13]=2)[C:9]([Cl:11])=[CH:10][C:2]=1[Cl:1]

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 521874O-Methylhydroxylamine hydrochlorideHCID 21254015HCID 21254015, compound

Product 1

HCID 21254039HCID 21254039, compound

Procedure

Using 5.2 g (14 mmol) of 2,4-dichloro-5-(5-difluoromethoxy-4-fluoro-1-methyl-1H-pyrazol-3-yl)benzoyl chloride, 19.2 g (0.14 mol) of potassium carbonate and 9.2 g (28 mmol) of a 25% strength aqueous methoxyamine hydrochloride solution and following the procedure described for Precursor 1.2, a crude product was obtained whose purification by means of silica gel chromatography (eluent:hexane/ethyl acetate=4:1) gave 1.5 g of the desired product of value.

Workup

  1. customa crude product was obtained
  2. customwhose purification by means of silica gel chromatography (eluent:hexane/ethyl acetate=4:1)

Sources & evidence

ORD record
ord-15c4f10e6c40485e8062bdbd07ed919e
Source dataset
uspto-grants-2001_03
Patent number
US06197973B1

Reaction notes

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