Allylamine → HCID 21250347, compound

HRID 1531729Notes

Reaction equation

HRID 1531729 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=O.C(N(CC)CC)C.[CH2:21]([NH2:24])[CH:22]=[CH2:23]>O1CCCC1>[CH2:21]([NH:24][C:4](=[O:6])[C:3]1[CH:7]=[C:8]([N+:11]([O-:13])=[O:12])[CH:9]=[CH:10][C:2]=1[Br:1])[CH:22]=[CH2:23]

Participants

5

Reactant 3

HCID 7853AllylamineHCID 8471TriethylamineHCID 2430252-Bromo-5-nitrobenzoic acid

Product 1

HCID 21250347HCID 21250347, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To a solution of 2.5 g (0.01 mol) of 2-bromo-5-nitro-benzoic acid in 70 ml tetrahydrofuran are added dropwise 3.2 g (0.01 mol) of O-(benzotriazol-1-yl)-N,N,N′N′-tetramethyluronium-tetrafluoroborate, 5 ml triethylamine and a solution of 570 mg (0.01 mol) of allylamine in 5 ml tetrahydrofuran. After 60 minutes at ambient temperature the mixture is poured onto ice water, the product precipitated is suction filtered, washed with water and dried.

Workup

  1. additionAfter 60 minutes at ambient temperature the mixture is poured onto ice water
  2. customthe product precipitated
  3. filtrationfiltered
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-3b7bdcac3c7c4eaa815857f5b3dc0201
Source dataset
uspto-grants-2001_03
Patent number
US06200976B1

Reaction notes

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