Water → HCID 86756531, compound

HRID 1531737Notes

Reaction equation

HRID 1531737 reaction equation
Cl.[CH3:2][O:3][C:4]([CH2:6][N:7]([S:30]([C:33]1[CH:34]=[CH:35][CH:36]=[C:37]2[C:42]=1[N:41]=[CH:40][CH:39]=[CH:38]2)(=[O:32])=[O:31])[C:8]1[CH:9]=[C:10]2[C:15](=[CH:16][CH:17]=1)[N:14]([CH3:18])[C:13](=[O:19])[C:12]([CH2:20][C:21]1[CH:29]=[CH:28][C:24]([C:25]([NH2:27])=[NH:26])=[CH:23][CH:22]=1)=[N:11]2)=[O:5].O.[C:44](=[O:47])([O-])[O-].[K+].[K+].ClC([O:53][CH2:54][CH3:55])=O>O1CCCC1>[CH3:2][O:3][C:4]([CH2:6][N:7]([S:30]([C:33]1[CH:34]=[CH:35][CH:36]=[C:37]2[C:42]=1[N:41]=[CH:40][CH:39]=[CH:38]2)(=[O:31])=[O:32])[C:8]1[CH:9]=[C:10]2[C:15](=[CH:16][CH:17]=1)[N:14]([CH3:18])[C:13](=[O:19])[C:12]([CH2:20][C:21]1[CH:22]=[CH:23][C:24]([C:25]([N:27]=[C:44]=[O:47])=[N:26][O:53][CH2:54][CH3:55])=[CH:28][CH:29]=1)=[N:11]2)=[O:5]

Participants

6

Reactant 4

HCID 962WaterHCID 10928Ethyl chloroformateHCID 11430Potassium CarbonateHCID 21250242HCID 21250242, compound

Product 1

HCID 86756531HCID 86756531, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

450 mg (0.74 mmol) of 4-{[6-(N-methoxycarbonylmethyl-quinolin-8-yl-sulphonylamino)-1-methyl-2-oxo-1,2-dihydroquinoxalin-3-yl]-methyl}benzamidine-hydrochloride are dissolved in 30 ml tetrahydrofuran and 5 ml water and after the addition of 0.3 g (2.2 mmol) of potassium carbonate, stirred for 10 minutes at ambient temperature. Then 0.07 ml (0.74 mmol) of ethyl chloroformate are added and stirred for a further 1 hour. The aqueous phase is separated off, the organic phase is dried and evaporated down.

Workup

  1. stirringstirred for a further 1 hour
  2. customThe aqueous phase is separated off
  3. customthe organic phase is dried
  4. customevaporated down

Sources & evidence

ORD record
ord-f2db4cda00a145cb8d8850f2f6b5b78e
Source dataset
uspto-grants-2001_03
Patent number
US06200976B1

Reaction notes

Loading…